Cardiovascular phenotypes predict clinical outcomes in sickle cell disease: An echocardiography?based cluster analysis

This study sought to link cardiac phenotypes in homozygous Sickle Cell Disease (SCD) patients with clinical profiles and outcomes using cluster analysis. We analyzed data of 379 included the French Etendard Cohort. A analyses was performed based on echocardiographic variables, association between clusters, assessed. Three clusters were identified. Cluster 1 (n = 123) had lowest output, mild left cavities remodeling, diastolic dysfunction, higher tricuspid regurgitation velocity (TRV). They predominantly female displayed most altered functional limitation. 2 102) highest output remodeled cavities. Diastolic function TRV similar 1. These a blood pressure severe hemolytic anemia. 3 154) normal values. younger hemoglobin value. Right heart catheterization 94 patients. 33) majority pre-capillary PH whilst 34) post-capillary PH. No found 27). After follow-up 11.4 ± years, death occurred 41 (11%). worst prognosis 19% mortality rate versus 12% 5% (p log-rank 0.003). analysis echocardiography variables identified three hemodynamic among SCD patients, each predicting different prognosis.